Review



jak2 inhibitor azd1480  (Santa Cruz Biotechnology)


Bioz Verified Symbol Santa Cruz Biotechnology is a verified supplier  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 96
      Buy from Supplier

    Structured Review

    Santa Cruz Biotechnology jak2 inhibitor azd1480
    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
    Jak2 Inhibitor Azd1480, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 4347 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 inhibitor azd1480/product/Santa Cruz Biotechnology
    Average 96 stars, based on 4347 article reviews
    jak2 inhibitor azd1480 - by Bioz Stars, 2026-02
    96/100 stars

    Images

    1) Product Images from "Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway."

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    Journal: Journal of orthopaedic surgery and research

    doi: 10.1186/s13018-024-04915-5

    Fig. 3 Effect of OSM on JAK2/STAT3 signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
    Figure Legend Snippet: Fig. 3 Effect of OSM on JAK2/STAT3 signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Techniques Used: Expressing, Western Blot, Two Tailed Test, Standard Deviation

    Fig. 4 OSM promotes early and mid-stage osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. (A, B,E)After 7 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alkaline phosphatase staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins as well as osteogenic marker genes was analysed by western blotting and qPCR(n = 3). One-way ANOVA. (C, D,F) After 14 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alizarin red staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins and osteogenic marker genes were analysed by western blotting and qPCR, respectively (n = 3). One-way ANOVA. Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
    Figure Legend Snippet: Fig. 4 OSM promotes early and mid-stage osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. (A, B,E)After 7 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alkaline phosphatase staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins as well as osteogenic marker genes was analysed by western blotting and qPCR(n = 3). One-way ANOVA. (C, D,F) After 14 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alizarin red staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins and osteogenic marker genes were analysed by western blotting and qPCR, respectively (n = 3). One-way ANOVA. Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Techniques Used: Staining, Expressing, Marker, Western Blot, Standard Deviation

    Fig. 5 OSM promotes osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. OSM binds to the tendon stem cell receptor OSMR/GP130, activating and phosphorylating JAK2. Phosphorylated JAK2 activates STAT3 downstream, and phosphorylated STAT3 forms a dimer that translocates to the nucleus and binds to DNA to regulate gene transcription. AZD1480 and stattic inhibit activation and phosphorylation of JAK2 and STAT3, respectively
    Figure Legend Snippet: Fig. 5 OSM promotes osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. OSM binds to the tendon stem cell receptor OSMR/GP130, activating and phosphorylating JAK2. Phosphorylated JAK2 activates STAT3 downstream, and phosphorylated STAT3 forms a dimer that translocates to the nucleus and binds to DNA to regulate gene transcription. AZD1480 and stattic inhibit activation and phosphorylation of JAK2 and STAT3, respectively

    Techniques Used: Activation Assay, Phospho-proteomics



    Similar Products

    jak2 inhibitor azd1480  (MedChemExpress)
    94
    MedChemExpress jak2 inhibitor azd1480
    Jak2 Inhibitor Azd1480, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 inhibitor azd1480/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    jak2 inhibitor azd1480 - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    resource source identifier jak2 inhibitor azd1480 medchemexpress cat  (MedChemExpress)
    94
    MedChemExpress resource source identifier jak2 inhibitor azd1480 medchemexpress cat
    Resource Source Identifier Jak2 Inhibitor Azd1480 Medchemexpress Cat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/resource source identifier jak2 inhibitor azd1480 medchemexpress cat/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    resource source identifier jak2 inhibitor azd1480 medchemexpress cat - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    jak2 inhibitor azd1480  (Santa Cruz Biotechnology)
    96
    Santa Cruz Biotechnology jak2 inhibitor azd1480
    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
    Jak2 Inhibitor Azd1480, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 inhibitor azd1480/product/Santa Cruz Biotechnology
    Average 96 stars, based on 1 article reviews
    jak2 inhibitor azd1480 - by Bioz Stars, 2026-02
    96/100 stars
    		  Buy from Supplier
    jak2 inhibitor azd1480  (Cayman Chemical)
    90
    Cayman Chemical jak2 inhibitor azd1480
    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
    Jak2 Inhibitor Azd1480, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 inhibitor azd1480/product/Cayman Chemical
    Average 90 stars, based on 1 article reviews
    jak2 inhibitor azd1480 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    jak2 inhibitor (azd1480  (Cayman Chemical)
    90
    Cayman Chemical jak2 inhibitor (azd1480
    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
    Jak2 Inhibitor (Azd1480, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 inhibitor (azd1480/product/Cayman Chemical
    Average 90 stars, based on 1 article reviews
    jak2 inhibitor (azd1480 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    jak2 specific inhibitor azd1480  (Selleck Chemicals)
    95
    Selleck Chemicals jak2 specific inhibitor azd1480
    Fig. 9 <t>JAK2-STAT3</t> signaling pathway inhibitors eliminate the adipose browning induced by SPX. The adipocytes were treated with an inhibitor of JAK2 <t>(AZD1480)</t> or an inhibitor of STAT3 (stattic). (A ~ D) The protein expression of UCP1, TBX1 and CIDEA treated with AZD1480 and stattic. (E) The expression levels of mitochondrial biogenesis proteins CYT-B. (F) The mRNA expression of UCP1, TBX1 and CIDEA. All values are represented as means with error bars representing S.D. In the bar graph, *, P < 0.05; **, P < 0.01. n = 6 for each group
    Jak2 Specific Inhibitor Azd1480, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 specific inhibitor azd1480/product/Selleck Chemicals
    Average 95 stars, based on 1 article reviews
    jak2 specific inhibitor azd1480 - by Bioz Stars, 2026-02
    95/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 3 Effect of OSM on JAK2/STAT3 signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Journal: Journal of orthopaedic surgery and research

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    doi: 10.1186/s13018-024-04915-5

    Figure Lengend Snippet: Fig. 3 Effect of OSM on JAK2/STAT3 signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Article Snippet: To further analyse the effect of JAK2/STAT3 signalling on osteogenic differentiation of TDSCs, JAK2 inhibitor AZD1480 (10 μM, Santa Cruz Biotechnology, Dallas, TX), STAT3 inhibitor stattic (5 μM, Santa Cruz Biotechnology), or DMSO was added to the osteogenic differentiation medium with 25 ng/mL recombinant OSM to differentiate TDSCs for 7 and 14 days.

    Techniques: Expressing, Western Blot, Two Tailed Test, Standard Deviation

    Fig. 4 OSM promotes early and mid-stage osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. (A, B,E)After 7 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alkaline phosphatase staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins as well as osteogenic marker genes was analysed by western blotting and qPCR(n = 3). One-way ANOVA. (C, D,F) After 14 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alizarin red staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins and osteogenic marker genes were analysed by western blotting and qPCR, respectively (n = 3). One-way ANOVA. Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Journal: Journal of orthopaedic surgery and research

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    doi: 10.1186/s13018-024-04915-5

    Figure Lengend Snippet: Fig. 4 OSM promotes early and mid-stage osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. (A, B,E)After 7 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alkaline phosphatase staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins as well as osteogenic marker genes was analysed by western blotting and qPCR(n = 3). One-way ANOVA. (C, D,F) After 14 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alizarin red staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins and osteogenic marker genes were analysed by western blotting and qPCR, respectively (n = 3). One-way ANOVA. Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Article Snippet: To further analyse the effect of JAK2/STAT3 signalling on osteogenic differentiation of TDSCs, JAK2 inhibitor AZD1480 (10 μM, Santa Cruz Biotechnology, Dallas, TX), STAT3 inhibitor stattic (5 μM, Santa Cruz Biotechnology), or DMSO was added to the osteogenic differentiation medium with 25 ng/mL recombinant OSM to differentiate TDSCs for 7 and 14 days.

    Techniques: Staining, Expressing, Marker, Western Blot, Standard Deviation

    Fig. 5 OSM promotes osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. OSM binds to the tendon stem cell receptor OSMR/GP130, activating and phosphorylating JAK2. Phosphorylated JAK2 activates STAT3 downstream, and phosphorylated STAT3 forms a dimer that translocates to the nucleus and binds to DNA to regulate gene transcription. AZD1480 and stattic inhibit activation and phosphorylation of JAK2 and STAT3, respectively

    Journal: Journal of orthopaedic surgery and research

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    doi: 10.1186/s13018-024-04915-5

    Figure Lengend Snippet: Fig. 5 OSM promotes osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. OSM binds to the tendon stem cell receptor OSMR/GP130, activating and phosphorylating JAK2. Phosphorylated JAK2 activates STAT3 downstream, and phosphorylated STAT3 forms a dimer that translocates to the nucleus and binds to DNA to regulate gene transcription. AZD1480 and stattic inhibit activation and phosphorylation of JAK2 and STAT3, respectively

    Article Snippet: To further analyse the effect of JAK2/STAT3 signalling on osteogenic differentiation of TDSCs, JAK2 inhibitor AZD1480 (10 μM, Santa Cruz Biotechnology, Dallas, TX), STAT3 inhibitor stattic (5 μM, Santa Cruz Biotechnology), or DMSO was added to the osteogenic differentiation medium with 25 ng/mL recombinant OSM to differentiate TDSCs for 7 and 14 days.

    Techniques: Activation Assay, Phospho-proteomics

    Fig. 9 JAK2-STAT3 signaling pathway inhibitors eliminate the adipose browning induced by SPX. The adipocytes were treated with an inhibitor of JAK2 (AZD1480) or an inhibitor of STAT3 (stattic). (A ~ D) The protein expression of UCP1, TBX1 and CIDEA treated with AZD1480 and stattic. (E) The expression levels of mitochondrial biogenesis proteins CYT-B. (F) The mRNA expression of UCP1, TBX1 and CIDEA. All values are represented as means with error bars representing S.D. In the bar graph, *, P < 0.05; **, P < 0.01. n = 6 for each group

    Journal: Nutrition & metabolism

    Article Title: Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway.

    doi: 10.1186/s12986-024-00790-3

    Figure Lengend Snippet: Fig. 9 JAK2-STAT3 signaling pathway inhibitors eliminate the adipose browning induced by SPX. The adipocytes were treated with an inhibitor of JAK2 (AZD1480) or an inhibitor of STAT3 (stattic). (A ~ D) The protein expression of UCP1, TBX1 and CIDEA treated with AZD1480 and stattic. (E) The expression levels of mitochondrial biogenesis proteins CYT-B. (F) The mRNA expression of UCP1, TBX1 and CIDEA. All values are represented as means with error bars representing S.D. In the bar graph, *, P < 0.05; **, P < 0.01. n = 6 for each group

    Article Snippet: Antibodies UCP1 (ab10983), TBX1 (ab109313) and CIDEA (ab8402) were purchased from Abcam (Cambridge, UK), Actin (AP0063), JAK2 (3230), STAT3 (12,640), p-JAK2 (3771) and p-STAT3 (9145) were from Cell Signaling Technology (Boston, MA, USA), and JAK2-specific inhibitor AZD1480 (S2162), STAT3-specific inhibitor stattic (S7024) was from Selleck.cn (Shanghai, China).

    Techniques: Expressing